Related Experiment Video
Updated: Dec 18, 2025
09:34
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
7.8K
Covalent Post-Assembly Modification: A Synthetic Multipurpose Tool in Supramolecular Chemistry
Haoxiang Zeng1, Luke Stewart-Yates1, Louis M Casey1
1School of Chemistry and Key Center for Polymers and Colloids, The University of Sydney, Sydney, NSW 2006, Australia.
Chempluschem
|June 13, 2020
Summary
Covalent post-assembly modification (PAM) is a powerful technique in supramolecular chemistry. PAM enables chemists to precisely control and enhance the properties of self-assembled materials and complexes.
Area of Science:
- Supramolecular Chemistry
- Materials Science
- Synthetic Chemistry
Background:
- Covalent post-assembly modification (PAM) has emerged as a significant synthetic strategy in supramolecular chemistry.
- PAM offers versatile methods for tuning, modulating, and expanding the functionality of self-assembled complexes and materials.
- It plays a crucial role in supramolecular template-synthesis, modular derivatization, stabilization of labile structures, and triggering morphological transformations.
Purpose of the Study:
- To review key examples and applications of covalent post-assembly modification (PAM) across various material classes.
- To highlight the evolution and creative utility of PAM in constructing bespoke self-assembled systems.
- To showcase PAM as an indispensable tool for synthetic chemists.
Main Methods:
- Discussion of key literature examples demonstrating PAM applications.
- Categorization of PAM examples across different material types: discrete supramolecular complexes, soft nanostructures, and hierarchical materials.
- Analysis of how PAM facilitates specific synthetic outcomes like functionalization and structural control.
Main Results:
- PAM is a versatile tool for modifying self-assembled structures after their initial formation.
- It enables the covalent 'locking' of unstable supramolecular assemblies, enhancing their stability.
- PAM facilitates controlled structural transformations and the creation of complex, hierarchical materials.
Conclusions:
- Covalent post-assembly modification (PAM) has evolved into a creative and functional addition to the synthetic chemist's toolkit.
- PAM provides precise control over the properties and structures of self-assembled materials.
- Its application spans diverse material classes, enabling the construction of bespoke supramolecular systems.
Related Concept Videos
01:16Cycloaddition Reactions: Overview
3.2K
Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
3.2K
02:04Covalently Linked Protein Regulators
8.5K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
8.5K
01:16Cycloaddition Reactions: MO Requirements for Thermal Activation
4.1K
Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
4.1K
02:00Molecular Models
43.2K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.2K
01:57Protein Complexes with Interchangeable Parts
2.8K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.8K
01:12Cycloaddition Reactions: MO Requirements for Photochemical Activation
2.5K
Some cycloaddition reactions are activated by heat, while others are initiated by light. For example, a [2 + 2] cycloaddition between two ethylene molecules occurs only in the presence of light. It is photochemically allowed but thermally forbidden.
2.5K