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A new treatment of alopecia induced by palbociclib: Topical cetirizine

Gemma Caro¹, Maria C Fortuna¹, Francesca Magri¹

¹Department of Ematology, Oncology and Dermatology, "Sapienza" University of Rome, Rome, Italy.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners

|June 13, 2020

Abstract

Introduction:

Recently CDK4/6 inhibitors have been introduced for the treatment of hormone positive breast cancer resistant to endocrine therapy. Among their side effects, alopecia is often reported being associated to patients' distress and depressive symptoms.

Case Report:

We report the case of a 70-year-old woman affected by breast cancer in treatment with Palbociclib, who developed alopecia.Management and Outcome: We prescribed a topical solution with cetirizine. Global photography, trichoscopy and trichogram were assessed. All evaluations demonstrated alopecia improvement.

Discussion:

Currently, no treatment options for CDK 4/6 inhibitors induced alopecia have been proposed. Herein, we report the use of topical cetirizine.

Keywords:

CDK4/6 inhibitors Topical cetirizine alopecia hair loss palbociblib

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