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[Inflammation in kidney diseases].

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Inflammation definitions evolved from symptoms to histopathology, and now molecular mediators. Using plasma biomarkers for kidney disease diagnosis may inflate the number of identified inflammatory conditions.

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Area of Science:

  • Nephrology
  • Immunology
  • Medical History

Background:

  • The concept of inflammation has evolved significantly throughout medical history.
  • Historically, inflammation was defined by observable symptoms.

Observation:

  • The definition shifted to histopathology, focusing on inflammatory infiltrates and cell types.
  • A molecular definition now emphasizes plasma mediators, expanding the scope of inflammatory diseases.

Findings:

  • Histopathological classification offers treatment advantages with corticosteroids and specific drugs.
  • Relying on plasma biomarkers for diagnosing inflammatory states, particularly in nephrology, can lead to an overdiagnosis of inflammatory kidney diseases.

Implications:

  • This evolving definition impacts disease classification and diagnostic criteria in nephrology.
  • A critical review of inflammation's definition is crucial for accurate diagnosis and treatment in kidney diseases.