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Published on: November 28, 2015
The Effect of Indicators of Systemic Inflammatory Response on Survival in Glioblastoma Multiforme
1University of Health Sciences, Istanbul Training and Research Hospital, Clinic of Radiation Oncology, Istanbul, Turkey.
Aim:
To evaluate the prognostic value of preoperative neutrophil-to-lymphocyte ratio and platelet-lymphocyte ratio in glioblastoma multiforme patients.
Material And Methods:
A total of 75 patients retrospectively analysed. The complete blood count of the patients was analysed before surgery. In our study, cut-off values for PLR 150 (platelet-lymphocyte ratio) and NLR 4 (neutrophil-to-lymphocyte ratio) were found to be significant by creating the ROC curve. Overall survival (OS) was calculated from surgery to death or the last contact. Progression-free survival (PFS) was calculated from surgery to progression. The last follow-up was November 2018.
Results:
The median OS was significantly shorter in PLR > 150 patients (p=0.005; 10 vs 17 months). And the median OS was significantly shorter in NLR > 4 patients too (p=0.010; 11 vs 17 months). In multivariate analysis, Karnofsky performance score < 70 (HR:2.96, 95% CI:1.68-5.21; p < 0.001), type of surgical resection (HR:2.32, 95% CI:1.35-3.98; p=0.002) were statistically significant for PFS. In multivariate analysis, KPS < 70 (HR:2.72, 95% CI:1.30-5.67; p < 0.007), type of surgical resection (HR:2.09, 95% CI:1.10- 3.95; p=0.023), NLR > 4 (HR:2.14, 95% CI:1.11-4.14; p=0.023) were statistically significant for OS were found to be independent prognostic factor.
Conclusion:
The presence of 70 < KPS and type of surgical resection in patients with GBM had a negative effect on PFS. NLR > 4, 70 < KPS, type of surgical resection were independent prognostic factors that negatively affect for the OS.
