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Functional Molecular Interfaces for Impedance-Based Diagnostics.

Prosper Kanyong¹, Amol V Patil¹, Jason J Davis¹

¹Department of Chemistry, University of Oxford, Oxford OX1 3QZ, United Kingdom;

Annual Review of Analytical Chemistry (Palo Alto, Calif.)

|June 13, 2020

Summary

This summary is machine-generated.

Optimizing reagentless electroanalytical assays requires careful selection of transducing interfaces. This review covers common receptive interfaces, bioreceptors, and immobilization strategies for enhanced impedimetric molecular sensors.

Keywords:

EIS antibodies aptamers biosensors electrochemical impedance spectroscopy nucleic acids sensory and responsive interfaces

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Area of Science:

Electrochemistry
Biosensors
Materials Science

Background:

Reagentless electroanalytical assays are crucial for sensitive and selective molecular detection.
The performance of these assays heavily relies on the characteristics of the transducing interface.

Purpose of the Study:

To review commonly used receptive interfaces for impedimetric molecular sensors.
To discuss various bioreceptors and immobilization techniques for assay optimization.

Main Methods:

Literature review of impedimetric sensor interfaces.
Discussion of high surface area carbon, nanoparticles, and diverse bioreceptors.
Analysis of immobilization chemistries, packing density, and probe orientation.

Main Results:

Identified high surface area carbon and nanoparticles as key interface materials.
Cataloged bioreceptors including antibodies, aptamers, nucleic acids, and emerging alternatives.
Highlighted the importance of immobilization strategies for sensor performance.

Conclusions:

Effective design of transducing interfaces is critical for reagentless electroanalytical assays.
A wide array of bioreceptors and immobilization methods can be employed to enhance sensor capabilities.
Understanding mechanistic details and real-world applications is essential for assay development.