Related Experiment Video
Updated: Dec 18, 2025

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
Published on: May 13, 2020
Concept and demonstration of a fully coupled and dynamic exposure-response methodology for crowd evacuation numerical
Nawayd Shaikh1, Konstantinos E Kakosimos1, Neil Adia1
1Department of Chemical Engineering and Mary Kay O'Connor Process Safety Center Qatar, Texas A&M University at Qatar, Qatar.
Abstract:
Evacuation simulation plays an indispensable role when planning for emergencies and evaluating the consequences of disasters related to airborne toxics. Various attempts have been made to improve simulation of evacuation in toxic environments and to account for the varying concentration levels and the dynamic exposure. However, most studies neglect the reverse effect, how the exposure and dosage levels affect the physical and psychological state of an evacuee and consequently the evacuation path and process. In this work, a fully coupled exposure-response-evacuation and agent based algorithm is proposed, focusing on the H2S airborne toxic. Accordingly, the dynamically estimated exposure of the evacuee affects, non-linearly, the evacuation speed and thus the overall evacuation. This coupling is challenging and thus it depends on the available epidemiological and toxicological data. Nevertheless, the diversity and advantages of the algorithm is successfully demonstrated over three case studies including single- and multi-agent in straight-path and building evacuation scenarios. For example, the building evacuation time increased by more than 50% by inclusion of the aforementioned coupling. In conclusion, herein, a gap on the evacuation modelling is addressed by a fully coupled methodology that could be easily adapted by safety engineers and further improved by researchers as more data become available.
Related Concept Videos
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Design Example: Analyzing Capacity Contours for Flood Risk Assessment
Response Surface Methodology
The process of RSM involves several key steps:

