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Current scenario of indole derivatives with potential anti-drug-resistant cancer activity

Yanshu Jia1, Xiaoyue Wen2, Yufeng Gong3

  • 1Chongqing Institute of Engineering, Chongqing, 400056, China.

European Journal of Medicinal Chemistry
|June 13, 2020
PubMed

Insights

Indole derivatives show promise in combating drug-resistant cancers. This review highlights their development and mechanisms for overcoming chemotherapy resistance.

Area of Science:

  • Medicinal Chemistry
  • Oncology
  • Drug Discovery

Background:

  • Drug resistance is a major challenge in cancer chemotherapy.
  • Indole derivatives offer potential therapeutic strategies against resistant cancer cells.
  • Several indole-containing compounds are already in clinical use for cancer treatment.

Purpose of the Study:

  • To review recent advancements in indole derivatives for drug-resistant cancer therapy.
  • To explore their mechanisms of action, design principles, and structure-activity relationships.

Main Methods:

  • Literature review of articles published between 2010 and 2020.
  • Focus on studies detailing the development and application of indole derivatives against drug-resistant cancers.

Main Results:

  • Indole derivatives exhibit diverse mechanisms against cancer cells.
  • Structure-activity relationship studies guide the design of potent anti-cancer agents.
  • Recent research shows significant progress in developing novel indole-based therapies.

Conclusions:

  • Indole derivatives are a valuable resource for developing new agents to overcome cancer drug resistance.
  • Further research into their design and mechanisms can lead to improved cancer treatments.
Keywords:
AlkaloidsAnticancerDimerDrug resistanceHybrid moleculesIndoleMechanisms of actionMetal complexMultidrug resistanceStructure-activity relationship

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