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Published on: November 10, 2023
Part I. SARS-CoV-2 triggered 'PANIC' attack in severe COVID-19
Elliot M Frohman1, Nicole R Villemarette-Pittman2, Esther Melamed3
1Department of Neurology, The Dell Medical School, The University of Texas at Austin, Austin, TX, United States of America; Department of Neurosurgery, The Dell Medical School, The University of Texas at Austin, Austin, TX, United States of America; Department of Ophthalmology, The Dell Medical School, The University of Texas at Austin, Austin, TX, United States of America.
Severe COVID-19 is defined as a
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Immunology
Background:
- COVID-19 pandemic caused global disruption.
- SARS-CoV-2 infects alveoli, crucial for gas exchange.
- Severe cases involve catastrophic immune responses in lung alveoli.
Purpose of the Study:
- Define severe COVID-19.
- Introduce the concept of 'PANIC' Attack in alveolar disease.
- Propose an immunotherapeutic strategy for severe COVID-19.
Main Methods:
- Characterization of severe COVID-19 pathophysiology.
- Definition of 'Prolific Activation of a Network-Immune-Inflammatory Crisis' (PANIC) Attack.
- Hypothesizing an immunotherapeutic intervention.
Main Results:
- Severe COVID-19 results from SARS-CoV-2 triggering a 'PANIC' Attack.
- This 'PANIC' Attack leads to alveolar obliteration and gas-exchange collapse.
- Part I defines the condition; Part II proposes a treatment hypothesis.
Conclusions:
- Severe COVID-19 is characterized by a 'PANIC' Attack in the alveoli.
- An immunotherapeutic approach targeting 'PANIC' may prevent or mitigate severe disease.
- Further clinical trials are needed to validate this therapeutic hypothesis.
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