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Blepharospasm, dry eye and extractable nuclear antigen antibodies
B C Girard1, M Abdellaoui1, G de Saint Sauveur1
1Service d'ophtalmologie, hôpital Tenon, Assistance publique-Hôpitaux de Paris, 4, rue de-la-Chine, 75970 Paris cedex 20, France; UPMC Sorbonne université, Paris, France.
Journal Francais D'Ophtalmologie
|June 14, 2020
Summary
This study suggests a link between benign essential blepharospasm and Sjögren's syndrome. Testing for anti-SSA/Ro and anti-SSB/La antibodies may be beneficial for patients with blepharospasm.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Benign essential blepharospasm (BEB) is a neurological disorder affecting eyelid muscles.
- Sjögren's syndrome is an autoimmune disease primarily targeting exocrine glands.
Purpose of the Study:
- To investigate a potential association between BEB and Sjögren's syndrome.
- To analyze the prevalence of extractable nuclear antigen antibodies in BEB patients.
Main Methods:
- 72 patients with BEB were assessed, excluding secondary causes.
- Schirmer I testing and anti-SSA/Ro and anti-SSB/La antibody levels were measured.
Main Results:
- 8% of female BEB patients tested positive for anti-SSA/Ro and anti-SSB/La antibodies.
- No significant difference in Schirmer I test results between antibody-positive and negative groups.
- Antibody-positive patients were, on average, younger than antibody-negative patients.
Conclusions:
- A possible association exists between Sjögren's syndrome and BEB.
- Recommend anti-SSA/Ro and anti-SSB/La antibody testing for BEB patients.
- Further research is warranted to elucidate the underlying mechanisms.
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