Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.8K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.8K
Lineage Commitment01:21

Lineage Commitment

3.9K
Commitment is the  process whereby stem cells:
3.9K
Hematopoiesis01:21

Hematopoiesis

8.1K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.1K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

723
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
723
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

7.9K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
7.9K
Blood Transfusion01:15

Blood Transfusion

2.0K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cationic carbon dot-silver nanohybrids with enhanced stability and redox control.

Discover nano·2026
Same author

Allogeneic Hematopoietic Cell Transplant Following Standard of Care Brexucabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia: Results from the Real-World Outcomes Collaborative of Chimeric Antigen Receptor T in Adult Acute Lymphoblastic Leukemia.

Transplantation and cellular therapy·2026
Same author

Overall survival of patients with chronic lymphocytic leukemia treated with venetoclax-obinutuzumab compared to age- and sex-matched general population.

Leukemia & lymphoma·2026
Same author

Improved Outcomes with TKI Maintenance Following Brexucabtagene Autoleucel in Philadelphia-chromosome ALL.

Blood advances·2026
Same author

Comparison of Fludarabine Versus Bendamustine as a Lymphodepleting Chemotherapy Prior to CAR-T for Large Cell Lymphoma.

Transplantation and cellular therapy·2026
Same author

Hemodiafiltration improves performance of 24 hour ex situ normothermic liver machine perfusion.

JHEP reports : innovation in hepatology·2026

Related Experiment Video

Updated: Dec 18, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.9K

Choosing Wisely® in Hematology: Have We Made a Difference?

Talal Hilal1, Javier Munoz2

  • 1Division of Hematology/Oncology, University of Mississippi Medical Center, Jackson, MS, USA. thilal@umc.edu.

Current Hematologic Malignancy Reports
|June 14, 2020
PubMed
Summary

The Choosing Wisely initiative promotes essential, evidence-based care. This review examines barriers, interventions, and measurement challenges for adopting these practices in hematology.

Keywords:
Choosing wiselyHarmsHealthcare costsValue-based

More Related Videos

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.7K
Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

1.2K

Related Experiment Videos

Last Updated: Dec 18, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.9K
Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.7K
Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

1.2K

Area of Science:

  • Healthcare policy
  • Medical practice guidelines
  • Patient safety

Background:

  • The Choosing Wisely® initiative, a global effort, encourages dialogue between patients and physicians on resource overutilization.
  • The American Society of Hematology advocates for specific hematology practices to improve patient care and reduce unnecessary procedures.

Purpose of the Study:

  • To review barriers hindering the adoption of Choosing Wisely® practices in hematology.
  • To identify interventions aimed at improving the implementation of evidence-based hematology care.
  • To discuss the challenges associated with measuring the effectiveness of these interventions on clinical outcomes and healthcare costs.

Main Methods:

  • Literature review of studies on Choosing Wisely® implementation in hematology.
  • Analysis of reported barriers to adopting recommended practices.
  • Synthesis of data on interventions and their measured impact.

Main Results:

  • Evidence on the positive impact of interventions on practice adoption is growing, but clinical outcome improvements remain uncertain.
  • Barriers to adoption include physician and patient perspectives, systemic issues, and lack of clear outcome data.
  • Measuring the effectiveness of interventions requires robust strategies to assess impact on physician behavior, patient attitudes, and healthcare economics.

Conclusions:

  • The transition to value-based healthcare necessitates a cultural shift towards essential, evidence-based practices.
  • Continued support for the Choosing Wisely® campaign requires improved methods for documenting and measuring the influence of value-based recommendations.
  • Further research is needed to establish clear links between intervention effectiveness, improved clinical outcomes, and reduced healthcare expenditures.