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Updated: Dec 18, 2025

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

Review article: Structural brain alterations in prelingually deaf.

Manja Hribar¹, Dušan Šuput², Saba Battelino³

¹Center for Clinical Physiology, Faculty of Medicine, University of Ljubljana, Slovenia; Clinic for Otorhinolaryngology and Cervicofacial Surgery, University Medical Centre Ljubljana, Slovenia; Department of Otorhinolaryngology, Faculty of Medicine, University of Ljubljana, Slovenia.

|June 14, 2020

Summary

Congenital deafness leads to significant brain structural changes, particularly in auditory white matter. These alterations are primarily driven by cross-modal plasticity and the use of sign language.

Keywords:

Brain Hearing loss Plasticity Prelingually deaf Structure

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Last Updated: Dec 18, 2025

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Area of Science:

Neuroscience
Neuroimaging
Auditory Neuroscience

Background:

The brain exhibits remarkable neuroplasticity, reorganizing in response to sensory deprivation.
Congenital deafness presents a unique model for studying brain adaptation without auditory input.

Purpose of the Study:

To review and synthesize findings on structural brain alterations in individuals with congenital deafness.
To identify common patterns and regions affected by the absence of hearing.

Main Methods:

Systematic review of studies investigating structural changes in the brains of congenitally deaf subjects.
Analysis of findings from whole-brain and region-of-interest investigations.

Main Results:

Predominant structural alterations observed in auditory white matter, especially in the right hemisphere.
Common findings include reduced white matter volume and fractional anisotropy in auditory areas.
Limited alterations noted in auditory grey matter, possibly due to cross-modal plasticity or methodological sensitivity.

Conclusions:

Structural brain alterations in congenital deafness are significant and widespread, extending beyond auditory regions.
Cross-modal plasticity, driven by the absence of sound and use of sign language, is the likely primary cause.
Preservation of grey matter may indicate compensatory mechanisms or limitations in current neuroimaging techniques.