A sensitive and visual molecularly imprinted fluorescent sensor incorporating CaF₂ quantum dots and β-cyclodextrins...

Calcium fluoride (CaF₂) quantum dots have many applications in various fields. But there is no report on fluorescent characteristics of CaF₂ quantum dots (CaF₂ QDs). Here, a synthesis of multiple-color emission CaF₂ QDs by changing the temperature, time and raw ratio is reported, by which the CaF₂ QDs with purple, blue, green, and yellow emission can be obtained, respectively. They were characterized by X-ray diffraction (XRD) and transmission electron microscope (TEM). On this basis, a novel molecular imprinting ratiometric fluorescence sensor (MIR sensor) had been constructed based on the prepared CaF₂ QDs and CdTe QDs, in which the yellow emission CaF₂ QDs was used as a responsive signal material and the red emission CdTe QDs was served as a reference signal material. And the β-CD and methylacrylic acid (MAA) as bifunctional monomers were used for constructing the specific molecularly imprinted polymers (MIPs) in MIR sensor. This MIR sensor was applied for highly selective and excellent sensitive detection of 5-hydroxymethylfurfural (HMF). Under optimum conditions, it exhibited an excellent linear relationship between the fluorescence intensity ratio (I₅₉₉/I₆₂₅) and the concentration of HMF in the range of 0.1-6.0 μg/mL with a detection limit of 0.043 μg/mL. Finally, the established HMF-MIR sensor was successfully utilized to detect HMF in honey with satisfactory results. This work provided a reference for the application of the CaF₂ QDs and the detection of the furfural substances.