Expanding statin use for prevention of ASCVD in Indians: Reasoned and simplified proposals

Area of Science:

• Cardiovascular Medicine
• Preventive Cardiology
• Public Health

Background:

• Atherosclerosis is the primary driver of cardiovascular disease (CVD), surpassing other causes like hypertension and arrhythmia.
• CVD claims 18 million lives globally each year, with coronary artery disease (CAD) accounting for 9 million.
• India faces a significant burden, with 2.64 million CVD deaths and 1.54 million CAD deaths in 2017, many premature.

Discussion:

• The high prevalence and mortality from CVD and CAD in India necessitate a shift from reactive treatments to proactive prevention.
• An editorial calls for increased statin utilization among Indians, supported by evidence on risk and risk-enhancing factors.
• A simplified, cost-effective approach to CVD prevention is proposed.

Key Insights:

• Statins offer a viable preventive strategy against atherosclerosis and its consequences.
• Risk stratification and early intervention are crucial for managing CVD in high-burden populations.
• Public health initiatives focusing on accessible and affordable treatments like statins can reduce premature mortality.

Outlook:

• Wider statin use in India could significantly lower CVD and CAD mortality rates.
• Further research into cost-effective CVD prevention strategies tailored to Indian demographics is warranted.
• A proactive public health approach integrating pharmacological interventions can combat the growing CVD epidemic.