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Clinical characteristics and long-term prognosis of ischemic and non-ischemic cardiomyopathy

Zhi-Hua Zhang1, Fan-Qi Meng2, Xiao-Feng Hou3

  • 1Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China; Department of Cardiology, Jiangning Hospital Affiliated to Nanjing Medical University, Jiangsu, China.

Indian Heart Journal
|June 15, 2020
PubMed

Insights

Prognostic risk factors differ between ischemic (ICM) and non-ischemic (NICM) heart failure. Identifying these distinct predictors is crucial for improving patient outcomes and guiding clinical management strategies.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Research

Background:

  • Heart failure (HF) prognosis varies significantly based on its underlying cause.
  • Differentiating between ischemic cardiomyopathy (ICM) and non-ischemic cardiomyopathy (NICM) is essential for accurate risk stratification.
  • Understanding specific prognostic factors for each HF etiology is clinically valuable.

Purpose of the Study:

  • To explore and identify the distinct predicting factors for prognosis in patients with ICM and NICM.
  • To compare the risk factors associated with all-cause mortality, sudden cardiac death (SCD), and rehospitalization for HF between ICM and NICM.

Main Methods:

  • Retrospective analysis of 873 patients with heart failure with reduced ejection fraction (HFrEF).
  • Patients were categorized into ICM and NICM groups.
  • Multivariate Cox regression analysis was employed to identify independent risk factors for mortality, SCD, and rehospitalization.

Main Results:

  • Patients with ICM exhibited higher rates of all-cause mortality and SCD compared to NICM.
  • Independent risk factors for all-cause mortality in ICM included diabetes mellitus, previous HF hospitalization, age, eGFR, and LVEF.
  • Distinct predictors for SCD and rehospitalization were identified for both ICM and NICM groups, highlighting etiological differences.

Conclusions:

  • Ischemic heart failure is associated with a worse prognosis, including higher all-cause mortality and SCD rates, than non-ischemic heart failure.
  • The risk factors influencing the prognosis of heart failure are significantly different depending on the underlying etiology (ICM vs. NICM).
Abstract

Keywords:
Chronic heart failureIschemic cardiomyopathyNon-ischemic cardiomyopathyThe prognosis

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