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Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

Cryptococcal meningitis in an immunocompetent patient.

Laura S Murphy¹, Aaron J Lacy¹, Austin T Smith¹

¹Department of Emergency Medicine, Vanderbilt University Medical Center, 1313 21st Ave, South, 703 Oxford House, Nashville, TN 37232-4700, United States of America.

The American Journal of Emergency Medicine

|June 15, 2020

Summary

Cryptococcal meningitis, a serious fungal infection, can occur in seemingly healthy individuals. This case highlights cryptococcal meningitis and fungemia in an immunocompetent patient, emphasizing the need for thorough investigation of persistent headaches.

Keywords:

Cryptococcus Cryptococcus neoformans var. grubii Elevated intracranial pressure Headache Immunocompetent Meningitis Opportunistic infection Papilledema

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Area of Science:

Infectious Diseases
Mycology
Neurology

Background:

Cryptococcal meningitis is typically an opportunistic infection in immunocompromised individuals, particularly those with Human Immunodeficiency Virus (HIV).
Complications include disseminated disease, intracranial hypertension, cerebral infarcts, vision loss, and other neurological deficits.

Observation:

A previously healthy male presented with persistent headaches after multiple emergency department visits.
Initial workup did not reveal any underlying condition leading to immune compromise.

Findings:

Lumbar puncture confirmed cryptococcal meningitis and fungemia.
The patient was admitted for antifungal therapy.

Implications:

This case underscores that cryptococcal meningitis can occur in immunocompetent individuals.
Highlights the importance of considering fungal infections in persistent headache presentations, even without apparent immune compromise.
Suggests potential for broader diagnostic considerations in infectious meningitis.