Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

2.9K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.9K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.6K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
The Endocrine System01:29

The Endocrine System

1.1K
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
1.1K
Obesity01:24

Obesity

1.0K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of Obesity with Thyroid hormones in Europe. Data from the THESIS* Collaboration.

Journal of endocrinological investigation·2024
Same author

Histopathological characteristics and post-operative follow-up of patients with potentially radiogenic papillary thyroid carcinoma depending on oncocytic changes availability in the tumor cells.

Experimental oncology·2019
Same author

Non-thyroid cancer in Northern Ukraine in the post-Chernobyl period: Short report.

Cancer epidemiology·2015
Same author

Reconstruction of individual thyroid doses to the Ukrainian subjects enrolled in the Chernobyl Tissue Bank.

Radiation protection dosimetry·2013
Same author

Estimating thyroid masses for children, infants, and fetuses in Ukraine exposed to (131)I from the Chernobyl accident.

Health physics·2012
Same author

Radiation induced thyroid cancer: fundamental and applied aspects.

Experimental oncology·2011

Related Experiment Video

Updated: Dec 18, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

609

[HORMONAL AND METABOLIC ASPECTS OF DIABETES-ASSOCIATED OSTEOARTHRITIS].

V Orlenko1, M Tronko1, S Bolgarskaya1

  • 11SI" V.P. Komisarenko Institute of Endocrinology and Metabolism NAMS of Ukraine».

Georgian Medical News
|June 15, 2020
PubMed
Summary

Elevated insulin and leptin levels are linked to joint damage in diabetes patients, indicating potential markers for diabetic arthropathy progression. Increased connective tissue breakdown is also observed in affected individuals.

More Related Videos

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

20.6K
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

3.3K

Related Experiment Videos

Last Updated: Dec 18, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

609
Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

20.6K
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

3.3K

Area of Science:

  • Endocrinology
  • Rheumatology
  • Biochemistry

Background:

  • Diabetes mellitus (DM) commonly causes joint damage via metabolic inflammation and increased catabolism.
  • Diabetic arthropathy, a complication of DM, involves significant joint structural changes.

Purpose of the Study:

  • To investigate insulin, leptin, osteocalcin, and connective tissue metabolism markers in diabetes-associated osteoarthritis.
  • To establish correlations between these markers and the severity of joint damage in diabetic patients.

Main Methods:

  • Enzyme immunoassay for serum insulin, leptin, and osteocalcin.
  • Biochemical analysis for glycosaminoglycans, hydroxyproline, hyaluronidase, and collagenase.
  • Categorization of 77 patients based on diabetes type and arthropathy severity.

Main Results:

  • Diabetic arthropathy found in over 70% of patients.
  • Significantly elevated insulin and leptin levels in patients with arthropathy, correlating with disease severity.
  • Increased hydroxyproline and collagenase indicate heightened connective tissue catabolism.

Conclusions:

  • Elevated insulin and leptin can serve as markers for arthropathy presence and progression in diabetes.
  • Increased catabolic markers (hydroxyproline, collagenase) suggest a mechanism for joint damage in diabetic patients.
  • Arthropathy development is not dependent on diabetes type, but women with type 2 diabetes show higher incidence.