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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

789
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

723
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

226
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Solid Organ Transplantation in Amyloidosis.

Foteini Theodorakakou1, Despina Fotiou1, Meletios A Dimopoulos1

  • 1Plasma Cell Dyscrasia Unit, Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.

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Amyloidosis causes organ damage through protein misfolding. Organ transplantation, particularly kidney transplants, offers improved outcomes for amyloidosis patients, though careful selection and experienced centers are crucial.

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Area of Science:

  • Medicine
  • Pathology
  • Transplantation

Background:

  • Amyloidosis is a group of diseases caused by misfolded proteins forming amyloid aggregates.
  • These aggregates deposit in organs, leading to progressive damage and potential organ failure.
  • Current therapies aim to reduce precursor protein levels, but organ transplantation is also explored.

Purpose of the Study:

  • To review the role and outcomes of organ transplantation in managing amyloidosis.
  • To highlight the benefits of transplantation, especially kidney transplants, in specific amyloidosis types.
  • To discuss the need for refined selection criteria and management protocols for amyloidosis patients undergoing transplantation.

Main Methods:

  • Review of existing literature on amyloidosis and organ transplantation outcomes.
  • Analysis of treatment strategies including chemotherapy, anti-inflammatory therapy, and antisense RNA therapy.
  • Evaluation of outcomes for heart and kidney transplantation in amyloidosis patients.

Main Results:

  • Kidney transplantation shows particularly favorable outcomes, especially when the precursor protein is eliminated.
  • Heart transplantation can be life-saving for advanced cardiac amyloidosis, despite historical contraindications.
  • Overall outcomes for solid organ transplantation in amyloidosis are improving.

Conclusions:

  • Organ transplantation is a viable treatment option for select amyloidosis patients, with kidney transplantation offering excellent results.
  • Further research is needed to optimize patient selection and timing for transplantation.
  • Transplantation should occur in experienced centers with multidisciplinary teams and close follow-up to monitor for recurrence.