Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

5.9K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.9K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.5K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.5K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.2K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

27.1K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.1K
Embryonic Stem Cells00:57

Embryonic Stem Cells

4.5K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
4.5K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.2K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular, cellular and network mapping of brain structural deviations in patients with Post-COVID19 syndrome.

Brain, behavior, & immunity - health·2026
Same author

Screening Performance of the DSM-5 Level 1 Cross-Cutting Symptom Measure to Detect Psychiatric Comorbidity Among Youth: A Community-Based Study.

Early intervention in psychiatry·2026
Same author

Brain dynamics of attentional, default-mode and limbic networks are disrupted at rest in post-COVID-19 syndrome.

Brain, behavior, & immunity - health·2026
Same author

The Lancet Commission on precision health: equitable, data-driven health outcomes for all.

Lancet (London, England)·2026
Same author

Exploring GPT-based models for depression detection in adolescents using naturalistic speech: A proof-of-concept study.

Journal of affective disorders·2026
Same author

Peripheral inflammation is associated with reduced influx of TSPO PET tracers into the brain: insights from a non-invasive mapping methodology.

Brain, behavior, and immunity·2026

Related Experiment Video

Updated: Dec 18, 2025

Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice
10:25

Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice

Published on: June 13, 2012

11.4K

Integrating stem cell-based experiments in clinical research.

Rakesh Karmacharya1,2, Christian Kieling3,4, Valeria Mondelli5,6

  • 1Program in Neuroscience and Chemical Biology, Center for Genomic Medicine, Massachusetts General Hospital & McLean Hospital, Harvard University, Boston, MA, USA.

European Psychiatry : the Journal of the Association of European Psychiatrists
|June 16, 2020
PubMed
Summary
This summary is machine-generated.

Patient-derived induced pluripotent stem cells (iPSCs) offer a powerful tool for neurological disease research. However, their integration into clinical studies for disease risk assessment remains limited, highlighting a critical research gap.

More Related Videos

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

11.1K
Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model
09:15

Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

Published on: November 5, 2011

14.3K

Related Experiment Videos

Last Updated: Dec 18, 2025

Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice
10:25

Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice

Published on: June 13, 2012

11.4K
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

11.1K
Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model
09:15

Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

Published on: November 5, 2011

14.3K

Area of Science:

  • Stem cell biology
  • Neuroscience
  • Genetics

Background:

  • Somatic cell reprogramming to generate patient-specific induced pluripotent stem cells (iPSCs) is a established laboratory technique.
  • iPSCs can be differentiated into mature neurons and three-dimensional brain organoids.
  • These neuronal models exhibit functional activity in electrophysiological studies.

Purpose of the Study:

  • To highlight the potential of patient-derived neuronal cells in disease risk studies.
  • To identify the gap in the clinical application of these cells for disease risk assessment.

Main Methods:

  • Review of current literature on induced pluripotent stem cell (iPSC) technology.
  • Analysis of the differentiation potential of iPSCs into neuronal cell types.
  • Electrophysiological studies of iPSC-derived neuronal models.

Main Results:

  • Patient-specific iPSCs can be reliably generated and differentiated into functional neurons and brain organoids.
  • These models demonstrate electrophysiological properties relevant to neurological function.

Conclusions:

  • Patient-derived iPSCs and their neuronal derivatives represent a valuable resource for studying neurological diseases.
  • There is a significant need to incorporate these patient-specific cells into clinical studies for disease risk evaluation.