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Ethnic differences in genetic polymorphism associated with irritable bowel syndrome
Qi-Yun Xiao1, Xiu-Cai Fang2, Xiao-Qing Li1
1Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
World Journal of Gastroenterology
|June 16, 2020
Summary
Genetic variations influence irritable bowel syndrome (IBS) risk and symptoms. This review highlights ethnic differences in IBS genetic studies, emphasizing the need for inclusive research to understand disease mechanisms and improve treatments.
Area of Science:
- Genetics
- Gastroenterology
- Epidemiology
Background:
- Genetic polymorphism is linked to irritable bowel syndrome (IBS) susceptibility and clinical features.
- Pathways like the gut-brain axis, motility, inflammation, and immunity are modulated by genetic factors in IBS.
- Ethnic variations in genetic studies of IBS warrant further investigation.
Purpose of the Study:
- To review studies on single nucleotide polymorphisms associated with IBS.
- To investigate ethnic disparities in IBS genetic research.
- To emphasize the importance of ethnic factors in understanding IBS pathophysiology.
Main Methods:
- Systematic review of published literature on IBS-associated single nucleotide polymorphisms.
- Analysis of genetic studies to identify ethnic variations and disparities.
- Synthesis of findings to highlight the role of ethnicity in IBS genetics.
Main Results:
- Significant ethnic differences were observed in genetic polymorphism studies related to IBS.
- Current genetic research on IBS often overlooks or underrepresents diverse ethnic backgrounds.
- Attention to ethnic factors is crucial for robust IBS genetic analysis.
Conclusions:
- Ethnic disparities are evident in IBS genetic research, necessitating greater focus on diverse populations.
- Incorporating ethnic considerations can strengthen transcultural and multi-ethnic IBS studies, including meta-analyses.
- Broader, ethnically-inclusive genetic studies are essential for advancing IBS understanding and management.
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