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Updated: Dec 18, 2025
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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
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Anaphylaxis to three humanized antibodies for severe asthma: a case study
Koichi Jingo1, Norihiro Harada1,2, Toshihiko Nishioki1
1Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431 Japan.
Summary
Anaphylaxis is a rare but serious side effect of asthma biologics like omalizumab, mepolizumab, and benralizumab. This case highlights the importance of careful monitoring for these treatments.
Area of Science:
- Pulmonology
- Allergy and Immunology
Background:
- Omalizumab, mepolizumab, benralizumab, and dupilumab are biologics for asthma in Japan.
- Anaphylaxis is a rare complication of mepolizumab and benralizumab therapy.
Observation:
- A 35-year-old woman with severe asthma developed anaphylaxis after receiving omalizumab, mepolizumab, and benralizumab sequentially.
- Biologic therapy was initiated to reduce systemic corticosteroid use for asthma exacerbations.
Findings:
- This is the first reported case of anaphylaxis to all three biologics (benralizumab, mepolizumab, omalizumab) in a single patient.
- The underlying mechanisms of anaphylaxis to these biologics are not yet understood.
Implications:
- Physicians should exercise caution when administering these biologics.
- Close patient monitoring for anaphylaxis is crucial during biologic asthma treatment.
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