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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

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Related Experiment Video

Updated: Dec 18, 2025

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

MicroRNA-7: expression and function in brain physiological and pathological processes.

Juanjuan Zhao¹, Ya Zhou², Mengmeng Guo^3,4

¹School of Medicine, Guizhou University, Guiyang, 550025 Guizhou China.

Cell & Bioscience

|June 16, 2020

Summary

This summary is machine-generated.

MicroRNA-7 (miR-7) is crucial for brain development and function. This review explores miR-7

Keywords:

Brain diseases Expression regulation MiR-7 Physiological function

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Last Updated: Dec 18, 2025

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

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Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

MicroRNAs (miRNAs) regulate gene expression post-transcriptionally, impacting physiological functions.
miRNAs are a research focus for brain development and diseases.
MicroRNA-7 (miR-7) is highly expressed in the mammalian brain and plays a role in various diseases.

Purpose of the Study:

To review the expression and function of miR-7 in brain development and disease.
To elucidate the role of miR-7 in physiological and pathological brain processes.
To highlight miR-7 as a potential biomarker and therapeutic target for brain diseases.

Main Methods:

Literature review of current scientific knowledge on miR-7.
Analysis of miR-7 expression regulation (gene transcription, precursor processing, mature sequence formation).
Examination of miR-7's physiological roles (pituitary, optic nerve, cerebral cortex) and pathological involvement (neurodegeneration, neuroinflammation, mental disorders).

Main Results:

miR-7 is predominantly expressed in sensory and neurosecretory neurons.
miR-7 regulates key developmental processes in the pituitary gland, optic nervous system, and cerebral cortex.
miR-7 influences multiple genes implicated in neurodegenerative diseases, neuroinflammation, and mental disorders.

Conclusions:

miR-7 is an intrinsic regulatory molecule in brain physiology and pathology.
Understanding miR-7's role offers insights into miRNA functions in brain development and disease.
Further research on miR-7 is vital for developing therapeutic strategies for brain diseases.