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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Recent advances in polymeric drug delivery systems.
Yong Kiel Sung1,2, Sung Wan Kim2
1Department of Chemistry, College of Science, Dongguk University, Phildong-ro, Seoul, 04620 South Korea.
Biomaterials Research
|June 16, 2020
Summary
Biodegradable and bio-reducible polymers are advancing drug delivery systems. Research combines natural and synthetic polymers for novel pharmaceutical applications, including cancer treatment.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Biotechnology
Background:
- Polymeric drug delivery systems have seen significant development over the last two decades.
- These systems are formulations or devices that introduce therapeutic substances into the body.
- Biodegradable and bio-reducible polymers are key materials enabling new drug delivery technologies.
Purpose of the Study:
- To review the advancements in polymeric drug delivery systems.
- To explore the use of natural and synthetic polymers in drug and gene delivery.
- To highlight the potential of these systems in pharmaceutical applications, particularly cancer treatment.
Main Methods:
- Discussion of natural polymers: arginine, chitosan, dextran, polysaccharides, poly(glycolic acid), poly(lactic acid), and hyaluronic acid.
- Analysis of synthetic polymers: poly(2-hydroxyethyl methacrylate), poly(N-isopropyl acrylamide)s, poly(ethylenimine)s, and dendritic polymers.
- Examination of polymeric gene delivery vectors, including viral and non-viral systems like polyethylenimine derivatives and conjugates.
Main Results:
- Polymeric drug delivery systems based on natural and synthetic polymers are rapidly advancing in pharmaceutical fields.
- Biocompatible copolymers and dendrimers show promise in cancer treatment as delivery systems for potent anticancer drugs.
- Progress has been made in targeted polymeric drug delivery, biomimetic systems, and drug-free macromolecular therapeutics.
Conclusions:
- The integration of synthetic and biological perspectives is crucial for designing next-generation polymeric drug and gene delivery systems.
- Continued research in this field is essential for practical applications and therapeutic breakthroughs.
- Polymeric systems offer a versatile platform for enhancing drug efficacy and patient outcomes.
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