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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
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Related Experiment Video

Updated: Dec 18, 2025

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
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Cutaneous leiomyosarcoma: dermal and subcutaneous.

Gwyneth Natalie Wong1, Angela Webb1,2, David Gyorki1,2

  • 1Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

The Australasian Journal of Dermatology
|June 16, 2020
PubMed
Summary
This summary is machine-generated.

Dermal leiomyosarcoma shows excellent prognosis with wide surgical excision. Subcutaneous leiomyosarcoma has poorer outcomes, necessitating wider excision and potentially adjuvant radiotherapy for better skin cancer treatment results.

Keywords:
atypical smooth muscle neoplasmcutaneous oncologydermatologic surgeryleiomyosarcomaskinsoft tissue tumours

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Area of Science:

  • Dermatology
  • Surgical Oncology
  • Pathology

Background:

  • Skin leiomyosarcoma (LMS) presents as either dermal or subcutaneous subtypes.
  • These rare tumors require distinct treatment strategies based on their classification.

Purpose of the Study:

  • To establish treatment recommendations for dermal and subcutaneous leiomyosarcoma.
  • To compare the clinical behavior and outcomes of these two LMS subtypes.

Main Methods:

  • Retrospective review of 83 patients with LMS managed between 2003-2018.
  • Analysis of tumor size, metastasis, recurrence, and treatment modalities including surgery and radiotherapy.

Main Results:

  • Subcutaneous LMS were significantly larger (49 mm vs 14 mm) and had higher metastasis rates (21% vs 0%).
  • 5-year survival was 88% for subcutaneous LMS versus 98% for dermal LMS.
  • Local recurrence rates were similar, and wide surgical excision (>10 mm margins) was key for local control.

Conclusions:

  • Dermal LMS has an excellent prognosis with adequate surgical margins.
  • Subcutaneous LMS requires wider excision and consideration of adjuvant radiotherapy due to poorer outcomes.
  • Definitive surgical excision is crucial for managing both LMS subtypes effectively.