Engineering Mono-Chalcogen Nanomaterials for Omnipotent Anticancer Applications: Progress and Challenges

Belonging to the chalcogen group, the elements selenium (Se) and tellurium (Te) are located in Group VI-A of the periodic table. Zero-valent nanodimensioned Se (nano-Se) and Te (nano-Te) have displayed important biomedical applications in recent years. The past two decades have witnessed an explosion in novel cancer treatment strategies using nano-Se and nano-Te as aggressive weapons against tumors. Indeed, they are both inorganic nanomedicines that suppress tumor cell proliferation, diffusion, and metastasis. Abundant synthesis strategies for rational and precise surface decoration of nano-Se and nano-Te make them significant players in resisting cancers by means of powerful multi-modal treatment methods. This review focuses on the design and engineering of nano-Se- and nano-Te-based nanodelivery systems and their precise uses in cancer treatment. The corresponding anticancer molecular mechanisms of nano-Se and nano-Te are discussed in detail. Given their different photo-induced behaviors, the presence or absence of near infrared illumination is used as a defining characteristic when describing the anticancer applications of nano-Se and nano-Te. Finally, the challenges and future prospects of nano-Se and nano-Te are summarized and highlighted.