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Age-Related Morbidity and Mortality among Patients with COVID-19

Seung Ji Kang1, Sook In Jung2

  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Infection & Chemotherapy
|June 16, 2020
PubMed

Insights

Older adults are more vulnerable to severe COVID-19 (coronavirus disease). This review examines age-related COVID-19 (coronavirus disease) risks and host responses to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection.

Area of Science:

  • Epidemiology
  • Immunology
  • Public Health

Background:

  • The COVID-19 pandemic, declared by WHO in March 2020, revealed age-related disparities in disease severity.
  • Understanding age-specific illness spectrum and pathogenic mechanisms is crucial for vulnerable populations.

Purpose of the Study:

  • To review COVID-19 epidemiology data globally to identify age-related trends in morbidity and mortality.
  • To explore literature on age-related differences in host responses to SARS-CoV-2 infection.

Main Methods:

  • Systematic review of published COVID-19 epidemiology data from multiple countries.
  • Literature review of studies investigating age-related host immune responses to SARS-CoV-2.

Main Results:

  • Consistent trends indicate increased COVID-19 morbidity and mortality with advancing age.
  • Evidence suggests age-related differences in immune system response to SARS-CoV-2 infection.

Conclusions:

  • Age is a significant factor influencing COVID-19 outcomes.
  • Insights gained can inform targeted treatment policies and preventive strategies for COVID-19, particularly for older adults.

Keywords:
AgeCOVID-19MorbidityMortalityPandemic

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