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Infant blood lipids: a systematic review of predictive value and influential factors

Isabella Theresa Felzer-Kim1, Joseph R Visker1, D P Ferguson1

  • 1Department of Kinesiology, Michigan State University , East Lansing, Michigan, United States.

Expert Review of Cardiovascular Therapy
|June 16, 2020
PubMed

Insights

Early infant blood lipid measurement, including total cholesterol and lipoproteins, can predict later childhood values and aid cardiovascular disease (CVD) prevention. Factors like sex, race, and feeding influence infant lipid levels, identifying at-risk infants.

Area of Science:

  • Pediatrics
  • Cardiology
  • Preventive Medicine

Background:

  • Current blood lipid screening for cardiovascular disease (CVD) risk begins at ages 9-11 years.
  • Fatty streaks in coronary arteries are evident by age 3, suggesting a need for earlier screening.
  • Earlier blood lipid measurement in infancy may enhance CVD prevention strategies.

Purpose of the Study:

  • To systematically review evidence on infant blood lipids (total cholesterol, LDL, HDL, triglycerides).
  • To assess the predictive value of infant blood lipids for later childhood values.
  • To identify factors influencing infant blood lipid levels.

Main Methods:

  • Systematic review of 38 articles published between 1965 and 2013.
  • Included studies examined infant blood lipids and their prediction of later values.
  • Analysis of factors influencing infant lipid concentrations.

Main Results:

  • Longitudinal data show correlations in most lipid values by 6 months of age, excluding triglycerides.
  • Infant blood lipid levels are influenced by sex, race, family history, feeding, gestational length, birth weight, and maternal factors.
  • Infant lipid measurements can serve as early markers for CVD.

Conclusions:

  • Infant blood lipid measurement offers potential as an early CVD marker.
  • Identifying individual factors associated with lipid levels can target early CVD prevention.
  • Personalized CVD prevention strategies can be developed by identifying vulnerable populations based on infant lipid profiles.
Abstract

Keywords:
Cholesterolcardiovascular disease preventioninfancylipidstriglycerides

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