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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Possible therapeutic agents for COVID-19: a comprehensive review

Khaled Mosaad Elhusseiny1,2,3, Fatma Abd-Elshahed Abd-Elhay4, Mohamed Gomaa Kamel4

  • 1Faculty of Medicine, Al-Azhar University , Cairo, Egypt.

Expert Review of Anti-Infective Therapy
|June 16, 2020
PubMed
Abstract

Insights

This review identifies potential therapeutic agents for COVID-19, including favipiravir and remdesivir. Combination therapies and routine patient monitoring are recommended for effective COVID-19 treatment.

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19, with no existing vaccines or antivirals.
  • The emergence of SARS-CoV-2 necessitates the identification of effective therapeutic strategies.

Purpose of the Study:

  • To review potential therapeutic agents for COVID-19.
  • To highlight promising treatments based on efficacy, safety, and pharmacokinetic profiles.

Main Methods:

  • Literature search of PubMed, Google Scholar, and clinicaltrials.gov.
  • Analysis of existing studies on therapeutic agents for COVID-19.

Main Results:

  • Several agents show potential efficacy and safety, though some were withdrawn due to side effects.
  • Effective therapies may include organ support, convalescent plasma, anticoagulants, and antiviral/immune therapies.
  • Favipiravir, remdesivir, and the measles vaccine are highlighted for further attention.

Conclusions:

  • Combination therapy (dual or triple) of efficacious and safe agents is recommended for COVID-19.
  • Routine monitoring of coagulation, bleeding, and cytokine profiles is advised for patients.
Keywords:
Coronavirusbatcovid-19drugimmunizationinfectionoutbreakpandemictherapyvaccine

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