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Related Concept Videos

Taste Buds and Receptors01:20

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Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
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The Physiology of Taste01:24

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The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
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Assessment of Social Transmission of Food Preferences Behaviors
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Selective Peripheral Taste Dysfunction in APP/PS1 Mutant Transgenic Mice.

Ryan M Wood1, Zacnite Garcia1, Nathan Daniels1

  • 1The University of Texas at San Antonio, Department of Biology, One UTSA Circle, San Antonio, TX, USA.

Journal of Alzheimer'S Disease : JAD
|June 16, 2020
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) models show reduced bitter taste sensitivity due to loss of taste receptor cells. This suggests peripheral taste dysfunction may contribute to taste impairments in AD.

Keywords:
APP/PS1 mutanttaste dysfunctiontaste receptor cells

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Area of Science:

  • Neuroscience
  • Sensory Biology
  • Alzheimer's Disease Research

Background:

  • Taste dysfunction is an early symptom in Alzheimer's disease (AD).
  • The cause of taste deficits in AD is debated, potentially involving peripheral or central mechanisms.

Purpose of the Study:

  • To investigate taste behavior and histology in APP/PS1 transgenic mice, an AD model.
  • To determine if APP/PS1 mice exhibit taste preference/avoidance deficits.
  • To ascertain if taste impairments stem from peripheral or central processing issues.

Main Methods:

  • Utilized APP/PS1 transgenic mice as an Alzheimer's disease model.
  • Assessed taste responses using a brief-access gustometer.
  • Employed immunohistochemistry on tongue, gustatory ganglion, and brain tissues.

Main Results:

  • APP/PS1 mice demonstrated significantly reduced bitter taste sensitivity.
  • A loss of TRPM5-expressing taste receptor cells was observed in the circumvallate papillae.
  • No significant loss of primary gustatory sensory neuron cell bodies was found, but axonal degeneration may play a role.

Conclusions:

  • Peripheral taste dysfunction, specifically the loss of taste receptor cells, is implicated in Alzheimer's disease.
  • Further research is needed to clarify the mechanisms and pathological significance of taste deficits in AD.