Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

123
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
123

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Family experiences of receiving treatment recommendations in a precision medicine trial for poor-prognosis childhood cancer.

NPJ genomic medicine·2026
Same author

Differential perforin sensitivity drives lineage-dependent resistance to CAR T-cell killing in blood cancer cell lines.

Blood advances·2026
Same author

Pharmacological inhibition of perforin dampens CD8<sup>+</sup> T cell-mediated beta cell destruction in autoimmune diabetes in mice.

Diabetologia·2026
Same author

Precision-guided therapy in H3K27-altered diffuse midline glioma.

Nature communications·2026
Same author

A single logic model capturing clinical, service, and implementation interventions using a practical example in pediatric precision medicine.

JBI evidence implementation·2026
Same author

A new hope: Clinical advances in targeted therapies for pediatric diffuse midline glioma.

Neuro-oncology advances·2026

Related Experiment Video

Updated: Dec 18, 2025

Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

7.4K

Immune profiling of pediatric solid tumors.

Rachael L Terry1, Deborah Meyran2,3,4, David S Ziegler1,5

  • 1Children's Cancer Institute, Randwick, New South Wales, Australia.

The Journal of Clinical Investigation
|June 16, 2020
PubMed
Summary

Pediatric solid tumors need better treatments. Immune profiling can guide personalized therapies like immune checkpoint inhibitors, improving outcomes for children with cancer.

More Related Videos

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

17.4K
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

9.0K

Related Experiment Videos

Last Updated: Dec 18, 2025

Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

7.4K
A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

17.4K
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

9.0K

Area of Science:

  • Oncology
  • Immunology
  • Translational Medicine

Background:

  • Pediatric high-risk solid tumors lack effective therapies, with outcomes unchanged for decades.
  • Immunotherapies, like immune checkpoint inhibitors, show promise but are largely adult-approved.
  • Few pediatric cancer trials use biomarkers to predict response to immunotherapy.

Purpose of the Study:

  • To review the current status of immune profiling in pediatric solid tumors.
  • To emphasize tumor types with high unmet clinical need for immunotherapy.
  • To discuss the potential of immune profiling for guiding pediatric cancer treatment.

Main Methods:

  • Review of existing literature on immune profiling in pediatric cancers.
  • Focus on studies related to immune checkpoint inhibitor therapy.
  • Emphasis on advanced multiplex techniques and their limited application.

Main Results:

  • Limited research exists on immune profiling for pediatric solid tumors, especially brain tumors.
  • Biomarker-guided trials and advanced multiplex techniques are underutilized in pediatric oncology.
  • Adult data shows immune profiling's predictive value, but translation to pediatric settings is scarce.

Conclusions:

  • Optimized immune profiling is crucial for effective pediatric cancer treatment.
  • Integrating immune profiling into standard practice can enable personalized combination therapies.
  • Addressing the unmet need in pediatric solid tumors requires advanced immune-based strategies.