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Vascularization strategies for skin tissue engineering.

Armin Amirsadeghi1, Arman Jafari, Loek J Eggermont

  • 1Department of Chemical Engineering, School of Chemical and Petroleum Engineering, Shiraz University, Shiraz 71348-51154, Iran. mkhorram@shirazu.ac.ir.

Biomaterials Science
|June 16, 2020
PubMed
Summary
This summary is machine-generated.

Skin tissue engineering aims to improve wound healing by using scaffolds, cells, and molecules. This review focuses on therapeutic vascularization strategies to overcome challenges in skin regeneration and promote healing.

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Skin grafting faces challenges in wound healing, prompting research into skin tissue engineering.
  • Tissue engineering utilizes scaffolds, cells, and bioactive molecules for skin repair.
  • Vascularization remains a critical limitation in engineered skin substitutes, leading to ischemia in large defects.

Purpose of the Study:

  • To review current therapeutic vascularization strategies in skin tissue engineering.
  • To summarize state-of-the-art approaches, their limitations, and recent advances.
  • To highlight solutions for improving vascular networks in skin substitutes.

Main Methods:

  • Review of literature on strategies to promote angiogenesis and prevascularization.
  • Classification of approaches into growth factor/nanoparticle/stem cell-based promotion of angiogenesis and prevascularization methods.
  • Analysis of limitations and advancements in therapeutic vascularization for skin regeneration.

Main Results:

  • Two main categories of strategies exist: promoting angiogenesis and prevascularization.
  • Approaches include growth factors, reactive oxygen species-inducing nanoparticles, and stem cells.
  • In vitro and in vivo prevascularization of skin grafts are also key strategies.

Conclusions:

  • Vascularization is essential for effective skin tissue engineering and wound healing.
  • Recent advances offer promising solutions for improving vascular networks in skin substitutes.
  • Continued research into therapeutic vascularization is crucial for overcoming limitations in skin regeneration.