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Phloroglucinol Derivatives from Myrtus communis 'Variegata' and Their Antibacterial Activities
Yan Wu1,2, Ming Chen1,2, Wen-Jing Wang1,2
1Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Abstract:
Myrtucomvalones D-F, three new triketone-phloroglucinol-triketone adducts, and three known ones (myrtucommulone E, myrtucommulone D and callistenone D) were obtained from Myrtus communis 'Variegata'. Myrtucomvalone D is a pair of enantiomers which was further resolved into (+)-myrtucomvalone D and (-)-myrtucomvalone D by chiral HPLC. Their structures and complete stereochemistry were established from interpretation of NMR and crystallographic data and chemical calculations. Myrtucomvalone F, myrtucommulone D and callistenone D showed significant antibacterial activities.
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