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Updated: Dec 18, 2025

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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Pancytopenia: a rare cause for a common presentation.

Subodh Kumar Mahto1, Akanksha Singh1, Ankita Aneja1

  • 1Senior Resident, Department of Medicine, Atal Bihari Vajpayee Institute of Medical Sciences & DR.RML Hospital, New Delhi, India.

Tropical Doctor
|June 17, 2020
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Summary

Filariasis, a tropical disease, can manifest unusually. This case highlights microfilaria in bone marrow causing pancytopenia, without typical lymphatic swelling.

Keywords:
Bone marrowfilariasispancytopenia

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Area of Science:

  • Medical Parasitology
  • Hematology
  • Public Health

Background:

  • Filariasis is a significant public health concern in tropical and subtropical regions, particularly in India.
  • Common clinical presentations include asymptomatic microfilaremia, elephantiasis, adenolymphangitis, and chronic lymphatic disease.

Observation:

  • A case report detailing microfilaria identified in bone marrow aspirates.
  • The patient presented with pancytopenia, a significant reduction in all blood cell types.

Findings:

  • The presence of microfilaria in bone marrow was confirmed.
  • The patient did not exhibit classical signs of lymphatic filariasis such as elephantiasis or lymphoedema.

Implications:

  • This case expands the known clinical spectrum of filariasis.
  • Highlights the importance of considering parasitic infections in unexplained cytopenias, even without overt lymphatic involvement.
  • Suggests bone marrow examination may be valuable in diagnosing atypical filariasis cases.