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Updated: Dec 18, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Study of tocopherol content and its potential antioxidant activity in commercial lipid emulsions for parenteral
A Novak1, M Gutiérrez-Zamora2, P Pérez-Lozano3
1Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, University of Barcelona, Spain;,
Abstract:
The objective of this study was to determine the content and evaluate the potential antioxidant effect of tocopherols in commercially available lipid emulsions, using a simple validated method adequate for further routine use. During the study, variability between manufacturers as well as between three non-consecutive batches of the same emulsion was observed. Furthermore, addition of α-tocopherol to lipid emulsions as excipient yields more stable emulsions and potentially a beneficial clinical effect. It was concluded that the variation of the tocopherol content between batches implies the importance of control and specification of tocopherol content by the manufacturers.
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