Related Experiment Video

Updated: Dec 18, 2025

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
07:55

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

1.5K

T Cells Targeting MAGE-A4 Shrink Tumors

    Cancer Discovery
    |June 17, 2020
    PubMed

    Insights

    Engineered T cells targeting MAGE-A4 cancer antigens show promise against solid tumors. This immunotherapy, ADP-A2M4, demonstrated significant tumor shrinkage and manageable side effects in early trials.

    Area of Science:

    • Oncology
    • Immunotherapy
    • Cancer Research

    Background:

    • Solid tumors present significant treatment challenges.
    • Cancer testis antigens like MAGE-A4 are potential therapeutic targets.
    • Autologous T cell therapy offers a personalized approach to cancer treatment.

    More Related Videos

    Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine09:15

    Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

    Published on: February 24, 2023

    3.8K
    Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care12:55

    Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

    Published on: February 16, 2015

    21.9K

    Related Concept Videos

    Tumor Immunotherapy01:27

    Tumor Immunotherapy

    Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
    1.6K
    Targeted Cancer Therapies02:57

    Targeted Cancer Therapies

    The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
    There are several types of targeted therapies against...
    8.5K