Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atomic Force Microscopy01:08

Atomic Force Microscopy

4.2K
Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering Photonic Pigments From Titania-Block Copolymer Composites.

Macromolecular rapid communications·2026
Same author

Label-Free Single Protein Dynamics Revealed by Metasurface-Enhanced Raman Spectroscopy.

ACS nano·2026
Same author

How the Electrochemical Double Layer Manipulates Molecule-Metal Interactions.

ACS nano·2026
Same author

Thermal transport through molecular monolayers in plasmonic nanogaps.

Nature communications·2026
Same author

Surface-Selective Molecular Binding and Replacement Selectivity in Plasmonic Nanocavities.

The journal of physical chemistry letters·2026
Same author

Coherent sum-frequency generation <i>via</i> continuous-wave laser excitation within plasmonic nanogap arrays.

Faraday discussions·2026

Related Experiment Video

Updated: Dec 18, 2025

All-electronic Nanosecond-resolved Scanning Tunneling Microscopy: Facilitating the Investigation of Single Dopant Charge Dynamics
11:33

All-electronic Nanosecond-resolved Scanning Tunneling Microscopy: Facilitating the Investigation of Single Dopant Charge Dynamics

Published on: January 19, 2018

10.1K

Cascaded nanooptics to probe microsecond atomic-scale phenomena.

Marlous Kamp1,2, Bart de Nijs3, Nuttawut Kongsuwan4

  • 1NanoPhotonics Centre, Department of Physics, University of Cambridge, Cambridge, CB3 0HE, United Kingdom; mkamp@cantab.net oas23@cam.ac.uk jjb12@cam.ac.uk.

Proceedings of the National Academy of Sciences of the United States of America
|June 17, 2020
PubMed
Summary

Researchers developed hybrid nanostructures combining refractive and plasmonic optics for enhanced Raman scattering. These novel devices achieve over 10^11 enhancement factors, enabling single-molecule detection with microsecond resolution.

Keywords:
few-molecule sensingmicrosecond integration timesnanolensingnanophotonicssurface-enhanced Raman scattering (SERS)

More Related Videos

Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals
10:35

Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals

Published on: May 29, 2018

9.1K
Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid
10:25

Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid

Published on: December 20, 2016

17.3K

Related Experiment Videos

Last Updated: Dec 18, 2025

All-electronic Nanosecond-resolved Scanning Tunneling Microscopy: Facilitating the Investigation of Single Dopant Charge Dynamics
11:33

All-electronic Nanosecond-resolved Scanning Tunneling Microscopy: Facilitating the Investigation of Single Dopant Charge Dynamics

Published on: January 19, 2018

10.1K
Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals
10:35

Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals

Published on: May 29, 2018

9.1K
Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid
10:25

Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid

Published on: December 20, 2016

17.3K

Area of Science:

  • Nanophotonics
  • Spectroscopy
  • Materials Science

Background:

  • Plasmonic nanostructures offer sub-diffraction light focusing and field enhancements for molecular detection.
  • Current plasmonic devices lack sufficient emission strength for high time-resolution tracking of molecular processes.

Purpose of the Study:

  • To develop advanced nanostructures for significantly enhanced Raman scattering efficiencies.
  • To enable real-time tracking of molecular-scale events with unprecedented time resolution.

Main Methods:

  • Fabrication of hybrid nanostructures by fusing silica (SiO2) nanospheres to plasmonic nanojunctions.
  • Characterization of Raman efficiencies and enhancement factors of the hybrid nanostructures.

Main Results:

  • Achieved Raman efficiencies of 10^7 counts⋅mW^-1⋅s^-1 and 5 × 10^5 counts∙mW^-1∙s^-1∙molecule^-1.
  • Demonstrated enhancement factors exceeding 10^11.
  • Enabled tracking of single gold atoms and molecules with 17-µs time resolution.

Conclusions:

  • Hybrid nanostructures significantly outperform conventional plasmonic devices for Raman scattering.
  • The developed system achieves megahertz count rates, rivaling and exceeding single-dye molecules and quantum dots.
  • These advancements open new possibilities for high-resolution, non-blinking molecular tracking.