Related Experiment Video
Updated: Dec 18, 2025

Murine Kidney Transplant Technique
Published on: October 20, 2015
Withdrawing mycophenolate mofetil in treating a young kidney transplant recipient with COVID-19: A case report
Dong Chen1,2, Bo Yang1,2, Yan Zhang3
1Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.
Rationale:
Coronavirus disease 2019 (COVID-19) is a novel infectious disease and became a global issue. Treatment of COVID-19 especially in solid organ transplant recipients is empirical and controversial, especially the adjustment of the immunosuppressants.
Patient Concerns:
A 29-year-old kidney transplant recipient with the symptoms of COVID-19 pneumonia.
Diagnoses:
COVID-19 pneumonia after kidney transplantation.
Interventions:
He was treated with modified immunosuppressants (unchanged dose of tacrolimus and oral corticosteroids while discontinuing mycophenolate mofetil (MMF)), antibiotics, interferon α-2b inhalation and traditional Chinese medicine.
Outcomes:
He recovered from COVID-19 pneumonia after 29 days of hospitalization. And the renal function (measured as blood urea nitrogen, serum creatinine, and urine protein) returned to normal.
Lessons:
In certain group of COVID-19 (e.g., mild to moderate cases, young patients without comorbidities), a reduction instead of an overall withdrawal of immunosuppressant in kidney transplant recipients is feasible.
Related Concept Videos
Kidney Transplant I: Introduction
Kidney Transplant III: Nursing Management
Kidney Transplant II: Surgical Procedure
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Chronic Kidney Disease II: Clinical Manifestations

