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Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

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Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
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Chronic Kidney Disease IV: Nursing Management01:18

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Updated: Dec 18, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
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Published on: May 30, 2025

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Impact of a Community-Based Weight Loss Program on Renal Function.

Tiffany E Schwasinger-Schmidt1, Georges Elhomsy1, Bobbie G Paull-Forney2

  • 1Internal Medicine, Kansas University School of Medicine-Wichita, Wichita, USA.

Cureus
|June 17, 2020
PubMed
Summary

Weight loss interventions improve kidney function in obese patients with chronic kidney disease (CKD). Lifestyle changes significantly boosted glomerular filtration rate (GFR) and reduced disease markers.

Keywords:
behavioral change in weight losscommunity based weight loss interventiondiabetes mellitushypertensionimproved ckd stagekidney functionlifestyle interventionnutrition and metabolismobesityweight loss

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Area of Science:

  • Nephrology
  • Metabolic Diseases
  • Public Health

Background:

  • Obesity is a significant risk factor for chronic kidney disease (CKD) progression and mortality.
  • Weight management interventions are crucial for mitigating obesity-related health complications.

Purpose of the Study:

  • To evaluate the impact of a community-based, lifestyle-focused weight-loss program on renal function in individuals with CKD.
  • To assess the association between weight loss and changes in glomerular filtration rate (GFR) and other metabolic markers.

Main Methods:

  • Retrospective analysis of 71 adults in a weight management program (2009-2014).
  • Intervention included meal replacements (≥800 kcal/day), weekly behavioral classes, and physical activity (≈300 kcal/day).
  • Primary outcome: association of weight loss with GFR changes; secondary outcomes: blood sugar, lipids, blood pressure, and medication use.

Main Results:

  • Average participant weight: 289 lbs, BMI: 53, baseline GFR: 47 ml/min/1.73m².
  • After 12 weeks, 76.1% improved CKD stage, with a significant correlation between weight loss and improved GFR (p=0.0006).
  • Improvements observed in blood sugar, blood pressure, and lipids (p<0.05); medication reduction for hypertension (61.8%) and diabetes (83.3%).

Conclusions:

  • A lifestyle-focused weight-loss intervention significantly correlates with improved renal function and CKD stage in obese individuals.
  • The intervention also improved metabolic markers and reduced medication needs for hypertension and diabetes.
  • Improved renal function persisted even when controlling for diabetes and hypertension.