Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.0K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.6K
Papillary Dermis01:11

Papillary Dermis

5.2K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioactive Peptides: A Comprehensive Critical Review of Structure-Activity Relationships, Molecular Mechanisms, and Translational Limitations.

The protein journal·2026
Same author

Parents' acceptance of human papilloma virus vaccination for their daughters in adet town, North Gojjam zone, Northwest Ethiopia: A mixed method study.

PloS one·2025
Same author

Does an Audio Wearable Lead to Agitation Reduction in Dementia: The Memesto AWARD Proof-of-Principle Clinical Research Study.

Research square·2025
Same author

Costs-effectiveness and cost components of pharmaceutical and non-pharmaceutical interventions affecting antibiotic resistance outcomes in hospital patients: a systematic literature review.

BMJ global health·2024
Same author

Colorectal Cancer Screening and Iron Deficiency Anemia.

Primary care·2023
Same author

Pulmonary Paragonimiasis: A Case Series.

JNMA; journal of the Nepal Medical Association·2023

Related Experiment Video

Updated: Dec 18, 2025

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.3K

A Case of Extensive Debilitating Generalized Morphea.

Amit Sapra1, Rebecca Dix1, Priyanka Bhandari1

  • 1Family Medicine, Southern Illinois University School of Medicine, Springfield, USA.

Cureus
|June 17, 2020
PubMed
Summary

Morphea, or localized scleroderma, is a rare skin condition causing firm, sclerotic plaques. Its exact cause is unknown, but it may involve autoimmune, genetic, and environmental factors.

Keywords:
chronic painimmunosuppressantsjoint painjoint restrictionmethotrexatemorphearare skin diseaserestriction of motionsclerodermaskin biopsy

More Related Videos

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.4K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.7K

Related Experiment Videos

Last Updated: Dec 18, 2025

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.3K
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.4K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.7K

Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Morphea, a type of localized scleroderma, is an uncommon idiopathic inflammatory skin disorder.
  • It characteristically presents as sclerotic plaques, predominantly affecting females.
  • The precise pathogenesis remains unclear, suggesting potential autoimmune, genetic, and environmental influences.

Observation:

  • Clinical presentations of morphea are diverse, initiating as inflammatory patches or plaques.
  • Lesions progress to firm, sclerotic changes, potentially involving deeper tissues like subcutaneous fat, muscle, or bone.
  • Diagnosis often relies on characteristic clinical findings, with biopsy aiding in complex cases.

Findings:

  • Morphea leads to the development of sclerotic skin plaques.
  • Disease involvement can range from superficial dermis to deep tissue structures.
  • Biopsies are recommended to assess disease depth and intensity when diagnosis is uncertain.

Implications:

  • Morphea can result in functional impairments, such as joint contractures, due to tissue sclerosis.
  • The condition can cause significant cosmetic and functional debilitation.
  • Further research into morphea's etiology is crucial for developing targeted treatments.