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Related Experiment Video

Updated: Dec 18, 2025

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Immune suppression in gliomas.

Matthew M Grabowski¹, Eric W Sankey¹, Katherine J Ryan¹

¹Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, 303 Research Drive, 220 Sands Bldg, Durham, NC, 27710, USA.

Journal of Neuro-Oncology

|June 17, 2020

Summary

This summary is machine-generated.

Gliomas suppress the immune system through various mechanisms, hindering treatment effectiveness. Overcoming this immunosuppression is crucial for developing new glioma therapies and improving patient survival.

Keywords:

Gbm Glioblastoma Glioma Immune suppression Immunosuppression Immunotherapy

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Published on: October 20, 2016

Area of Science:

Neuro-oncology
Immunology
Cancer Biology

Background:

Despite advances like immunotherapy, overall survival for glioma patients remains poor.
Gliomas possess a unique ability to suppress both local and systemic immune responses, limiting treatment efficacy.

Purpose of the Study:

To review preclinical and clinical evidence of immune suppression in gliomas.
To discuss how gliomas exploit the immune system for survival and proliferation.

Main Methods:

Comprehensive literature review of glioma immunosuppression.
Analysis of mechanisms employed by gliomas to evade immune detection.

Main Results:

Gliomas utilize multiple strategies to evade immune detection, including T-cell and NK cell dysfunction.
Expansion of regulatory T-cells and myeloid-derived suppressor cells contributes to immune evasion.
Tumor microenvironment factors like hypoxia and M2 macrophage polarization enhance immunosuppression.

Conclusions:

Gliomas establish a highly immunosuppressive environment, both locally and systemically.
Targeting these immunosuppressive mechanisms is essential for developing effective glioma treatments.
Future research should focus on overcoming glioma-induced immunosuppression to improve patient survival outcomes.