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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Genetic Risk Factors for Diverticular Disease-Emerging Evidence
1Division of Colorectal Surgery, Department of Surgery, University of Michigan, 2922 Taubman Canter, 1500 Medical Center Drive, Ann Arbor, MI, 48109, USA. maguirel@med.umich.edu.
Abstract:
Diverticular disease is traditionally understood as an environmental disease caused by diet and constipation. However, genes are increasing understood to play a role in pathogenesis. Twin studies suggest a substantial component of individual risk is due to heritable factors. Association of diverticular disease with other traits suggests an underlying biological mechanism and recently genome-wide association studies have described the genetic architecture underlying this complex phenotype. These studies suggest a new paradigm for understanding this common surgical disease.
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