Compositae sensitization in Danish children and adolescents

Area of Science:

• Dermatology
• Allergology
• Pediatrics

Background:

• Compositae plant sensitization is a common issue in children.
• Previous studies (1995-2006) showed a 1.8% prevalence of sesquiterpene lactone (SL) mix/parthenolide patch test positives in pediatric eczema patients.
• This highlights the need for ongoing surveillance of plant-related allergies in pediatric populations.

Purpose of the Study:

• To evaluate the efficacy of patch test screening for Compositae sensitization in individuals under 18 years old.
• To assess the diagnostic utility of SL mix, Compositae mix, and dandelion extract in pediatric patients.
• To determine the prevalence and characteristics of Compositae sensitization in children over a 13-year period.

Main Methods:

• A retrospective analysis of children and adolescents under 18 diagnosed with Compositae sensitization between 2007 and 2019.
• Patch testing was performed using SL mix, Compositae mix 5% pet., and dandelion extract 2.5% pet.
• Patient demographics, clinical history (atopy, hand eczema), and sensitization patterns were recorded.

Main Results:

• Out of 388 children tested, 12 (3%) showed Compositae sensitization, with 11 (2.8%) positive to SL mix.
• Compositae mix and dandelion extract showed high positivity rates in tested patients.
• The majority of sensitized children had a history of atopy or hand eczema, and only two were mono-sensitized.

Conclusions:

• Sesquiterpene lactone (SL) mix is a valuable and effective screening tool for Compositae sensitization in children and adolescents.
• Compositae mix and dandelion extract serve as useful adjuncts for diagnosis.
• Screening for Compositae sensitization is recommended in children with atopic history, hand eczema, or specific dermatitis patterns.