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Review and Prospect of Tissue-agnostic Targeted Strategies in Anticancer Therapies
Yu Peng1, Hongxun Tao2, Yuanqing Gao1
1Jiangsu Provincial Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Abstract:
Due to the increasing prevalence of cancer year by year, and the complexity and refractory nature of the disease itself, it is required to constantly innovate the development of new cancer treatment schemes. At the same time, the understanding of cancers has deepened, from the use of chemotherapy regimens with high toxicity and side effects, to the popularity of targeted drugs with specific targets, to precise treatments based on tumor characteristics rather than traditional anatomical location classification. In precision medicine, in the view of the specific cancer diseases and their biological characteristics, there is a great potential to develop tissue-agnostic targeted therapy with broad-spectrum anticancer significance. The present review has discussed tissue-agnostic targeted therapy based on the biological and genetic characteristics of cancers, expounded its theoretical basis and strategies for drug development. In addition, the feasible drug targets, FDA-approved drugs, as well as drug candidates in clinical trials have also been summarized. In conclusion, the "tissue-agnostic targeted therapy" is a breakthrough in anticancer therapies.
Insights
Tissue-agnostic targeted therapy represents a breakthrough in cancer treatment, focusing on biological characteristics rather than tumor location. This innovative approach offers broad-spectrum anticancer potential, advancing precision medicine.
Area of Science:
- Oncology
- Genetics
- Pharmacology
Background:
- Cancer treatment is evolving from toxic chemotherapy to targeted therapies based on specific tumor characteristics.
- Precision medicine necessitates innovative approaches beyond traditional anatomical classifications.
Purpose of the Study:
- To review the concept and development strategies of tissue-agnostic targeted therapy.
- To summarize feasible drug targets and relevant therapies in clinical development.
Main Methods:
- Literature review of tissue-agnostic targeted therapy.
- Analysis of biological and genetic cancer characteristics.
- Summary of drug targets, FDA-approved drugs, and clinical trial candidates.
Main Results:
- Tissue-agnostic targeted therapy leverages specific cancer biomarkers for broad-spectrum efficacy.
- Identified feasible drug targets and summarized approved and investigational therapies.
- Highlighted the potential of this approach in advancing precision oncology.
Conclusions:
- Tissue-agnostic targeted therapy is a significant advancement in cancer treatment.
- This approach holds great promise for developing broad-spectrum anticancer drugs.
- Further development is crucial for realizing the full potential of precision medicine in oncology.
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