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Updated: Dec 18, 2025

Quantifying Myeloperoxidase-DNA and Neutrophil Elastase-DNA Complexes from Neutrophil Extracellular Traps by Using a Modified Sandwich ELISA
Published on: May 12, 2023
SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and
Alain R Thierry1, Benoit Roch2
1Research Institute of Cancerology of Montpellier, INSERM U1194, IRCM, ICM, Université de Montpellier, Montpellier, F-34298, France.
Abstract:
We demonstrate that the general clinical conditions, risk factors and numerous pathological and biological features of COVID-19 are analogous with various disorders caused by the uncontrolled formation of neutrophil extracellular traps and their by-products. Given the rapid evolution of this disease's symptoms and its lethality, we hypothesize that SARS-CoV2 evades innate immune response causing COVID-19 progresses under just such an amplifier loop, leading to a massive, uncontrolled inflammation process. This work allows us to propose new strategies for treating the pandemic.
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