3D whole-heart isotropic-resolution motion-compensated joint T₁ /T₂ mapping and water/fat imaging

To develop a free-breathing isotropic-resolution whole-heart joint T₁ and T₂ mapping sequence with Dixon-encoding that provides coregistered 3D T₁ and T₂ maps and complementary 3D anatomical water and fat images in a single ~9 min scan.

Four interleaved dual-echo Dixon gradient echo volumes are acquired with a variable density Cartesian trajectory and different preparation pulses: 1) inversion recovery-preparation, 2) and 3) no preparations, and 4) T₂ preparation. Image navigators are acquired to correct each echo for 2D translational respiratory motion; the 8 echoes are jointly reconstructed with a low-rank patch-based reconstruction. A water/fat separation algorithm is used to obtain water and fat images for each acquired volume. T₁ and T₂ maps are generated by matching the signal evolution of the water images to a simulated dictionary. Complementary bright-blood and fat volumes for anatomical visualization are obtained from the T₂ -prepared dataset. The proposed sequence was tested in phantom experiments and 10 healthy subjects and compared to standard 2D MOLLI T₁ mapping, 2D balance steady-state free precession T₂ mapping, and 3D T₂ -prepared Dixon coronary MR angiography.

High linear correlation was found between T₁ and T₂ quantification with the proposed approach and phantom spin echo measurements (y = 1.1 × -11.68, R² = 0.98; and y = 0.85 × +5.7, R² = 0.99). Mean myocardial values of T₁ /T₂ = 1116 ± 30.5 ms/45.1 ± 2.38 ms were measured in vivo. Biases of T₁ /T₂ = 101.8 ms/-0.77 ms were obtained compared to standard 2D techniques.

The proposed joint T₁ /T₂ sequence permitted the acquisition of motion-compensated isotropic-resolution 3D T₁ and T₂ maps and complementary coronary MR angiography and fat volumes, showing promising results in terms of T₁ and T₂ quantification and visualization of cardiac anatomy and pericardial fat.