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Updated: Dec 18, 2025

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
Published on: February 16, 2017
Skeletal muscle aging - Stem cells in the spotlight
Henriette Henze1, M Juliane Jung1, Hellen E Ahrens1
1Leibniz-Institute on Aging - Fritz-Lipmann-Institute, Beutenbergstrasse 11, 07745 Jena, Germany.
Abstract:
Aging is characterized by a progressive decline in tissue and organ function often linked to a reduced stem cell functionality, a cell population important for regeneration. Skeletal muscle mass and regenerative capacity decrease with advancing age. Muscle stem cells, also termed satellite cells, are a prerequisite for regeneration of skeletal muscle. Their functionality declines with increasing age, driven by intrinsic changes and changes in the stem cell niche. Here, we discuss the current understanding how muscle stem cells are affected during aging. The aging associated alterations include among others upregulation of developmental pathways in aged muscle stem cells and changes in the extracellular matrix.
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