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Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
Published on: February 16, 2017
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Skeletal muscle aging - Stem cells in the spotlight
Henriette Henze1, M Juliane Jung1, Hellen E Ahrens1
1Leibniz-Institute on Aging - Fritz-Lipmann-Institute, Beutenbergstrasse 11, 07745 Jena, Germany.
Mechanisms of Ageing and Development
|June 17, 2020
Summary
Aging impairs skeletal muscle regeneration by reducing muscle stem cell (satellite cell) function. This decline is due to intrinsic cell changes and alterations in the stem cell niche, affecting tissue repair.
Area of Science:
- Gerontology and regenerative medicine, focusing on cellular aging and tissue repair mechanisms.
Background:
- Aging leads to a decline in tissue and organ function, primarily due to reduced stem cell functionality.
- Skeletal muscle mass and regeneration capacity diminish with age, impacting mobility and recovery.
Purpose of the Study:
- To review the current understanding of how aging affects muscle stem cells (satellite cells).
- To identify key molecular and environmental factors contributing to age-related decline in muscle stem cell function.
Main Methods:
- Review of existing literature on aging, stem cell biology, and skeletal muscle regeneration.
- Analysis of intrinsic cellular changes and extrinsic niche modifications impacting aged muscle stem cells.
Main Results:
- Aged muscle stem cells exhibit altered functionality, including the upregulation of developmental pathways.
- Changes in the extracellular matrix of the stem cell niche contribute to impaired regenerative capacity.
- Intrinsic cellular aging processes further compromise satellite cell performance.
Conclusions:
- Aging significantly impairs skeletal muscle stem cell function, hindering tissue regeneration.
- Understanding these age-associated alterations is crucial for developing interventions to enhance muscle repair in older individuals.
Keywords:
AgingMuscle stem cellMyogenesisNeuromuscular junctionNicheRegenerationSatellite cellSkeletal muscleStem cellMore Related Videos
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