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Updated: Dec 18, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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Sestrin 2 controls the cardiovascular aging process via an integrated network of signaling pathways

Yunxia Liu1, Xiaoyu Du1, Zhehao Huang2

  • 1Cardiovascular Center, First Hospital of Jilin University, Changchun, Jilin, 130021, China.

Ageing Research Reviews
|June 17, 2020
PubMed

Insights

Sestrin 2 (Sesn2) protein slows cardiovascular aging and combats age-related cardiovascular diseases through antioxidant and signaling pathway regulation. This review explores Sesn2

Area of Science:

  • Biochemistry and Molecular Biology
  • Cardiovascular Research
  • Aging and Gerontology

Background:

  • Cardiovascular aging is a primary risk factor for cardiovascular diseases (CVDs).
  • Sestrin 2 (Sesn2) is a stress-inducible protein implicated in mitigating aging processes.
  • Sesn2's role in cardiovascular health and disease is increasingly recognized.

Purpose of the Study:

  • To review the biochemical functions of Sesn2 in cardiovascular aging.
  • To describe Sesn2 expression regulation under stress.
  • To emphasize Sesn2's role in age-related CVDs and explore therapeutic potential.

Main Methods:

  • Literature review of Sesn2's biochemical functions.
  • Analysis of Sesn2 regulation under stress conditions.
  • Examination of Sesn2 signaling in age-related cardiovascular diseases.

Main Results:

  • Sesn2 exhibits antioxidant activity and regulates antioxidant pathways.
  • Sesn2 activates adenosine monophosphate-activated protein kinase (AMPK) and inhibits mTORC1.
  • Sesn2 signaling is linked to hypertension, ischemia-reperfusion injury, atherosclerosis, and heart failure.

Conclusions:

  • Sesn2 acts as a crucial anti-aging agent in the cardiovascular system.
  • Sesn2 plays a significant role in the pathophysiology of various age-related CVDs.
  • Targeting Sesn2 presents promising therapeutic strategies for cardiovascular aging and disease.
Keywords:
AgingCardiac agingCardiovascular diseaseSestrin 2

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