[Influence of fasting and the dietary lipid content on ketogenesis in isolated rabbit hepatocytes]

Ketogenesis was measured in isolated liver cells from fed or 48 h starved rabbits given either a low fat diet (3%) or a high fat diet (18%). In the fed rabbits, ketogenesis with butyrate, octanoate and oleate was greatly enhanced by the high fat diet. In the starved animals the increase in ketogenesis was moderate and only observed with oleate and butyrate. Results are discussed in relation to in vivo observations.