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New pharmacotherapy for heart failure with reduced ejection fraction
Sara Sotirakos1, Peter Wheen1,2, James Spiers1
1School of Medicine, Trinity College Dublin , Dublin, Ireland.
Expert Review of Cardiovascular Therapy
|June 18, 2020
Summary
New heart failure medications, sacubitril/valsartan (angiotensin receptor-neprilysin inhibitor) and dapagliflozin (SGLT2 inhibitor), significantly reduce mortality in patients with heart failure with reduced ejection fraction (HFrEF).
Area of Science:
- Cardiology
- Pharmacology
- Internal Medicine
Background:
- Current heart failure with reduced ejection fraction (HFrEF) guidelines recommend ACE inhibitors/ARBs and Beta Blockers.
- Newer pharmacotherapies, including ARNI (sacubitril/valsartan) and SGLT2 inhibitors (dapagliflozin), offer improved outcomes.
Purpose of the Study:
- To review the evidence for sacubitril/valsartan and dapagliflozin in HFrEF treatment.
- To analyze the impact of these novel therapies on mortality and disease modification.
Main Methods:
- Comprehensive literature review of sacubitril/valsartan and dapagliflozin in HFrEF.
- Searches conducted in NCBI and Google Scholar using relevant keywords.
- Examination of reference sections for additional relevant studies.
Main Results:
- Sacubitril/valsartan demonstrated benefits in mortality for HFrEF patients.
- Dapagliflozin also showed significant mortality benefits when added to existing therapies.
- Both agents represent advancements in HFrEF pharmacotherapy.
Conclusions:
- Sacubitril/valsartan and dapagliflozin are effective in reducing mortality in HFrEF.
- Further research is needed to fully elucidate their mechanisms of action in disease modification.
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