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Related Concept Videos

Binge Eating Disorders01:23

Binge Eating Disorders

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Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
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Bulimia Nervosa01:30

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Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
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Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Human Genetics01:28

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: Dec 18, 2025

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms
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The Binge Eating Genetics Initiative (BEGIN): study protocol.

Cynthia M Bulik1,2,3, Jonathan E Butner4, Jenna Tregarthen5

  • 1Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA. cbulik@med.unc.edu.

BMC Psychiatry
|June 18, 2020
PubMed
Summary
This summary is machine-generated.

The Binge Eating Genetics Initiative (BEGIN) investigates how genes, gut bacteria, and behaviors influence bulimia nervosa and binge-eating disorder. This research aims to predict illness risk and treatment response for personalized medicine.

Keywords:
Binge eatingEating disordersGeneticsMicrobiomeMobile applicationWearable technology

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Area of Science:

  • Genetics
  • Microbiome Research
  • Behavioral Science

Background:

  • Bulimia nervosa and binge-eating disorder are complex conditions with multifactorial etiologies.
  • Understanding the interplay of biological and behavioral factors is crucial for effective treatment.

Purpose of the Study:

  • To investigate the interplay of genomic, gut microbiota, and behavioral factors in eating disorders.
  • To identify predictors of risk, illness course, and treatment response.
  • To lay the foundation for a personalized precision medicine approach.

Main Methods:

  • Recruiting 1000 individuals diagnosed with bulimia nervosa or binge-eating disorder.
  • Collecting saliva for genotyping and fecal samples for microbiota analysis.
  • Utilizing the Recovery Record app on Apple Watch for 30-day passive data and behavioral phenotyping.

Main Results:

  • This study is ongoing; results are not yet available.
  • The study aims to collect comprehensive data on genetic, microbial, and behavioral factors.

Conclusions:

  • The Binge Eating Genetics Initiative (BEGIN) seeks to advance understanding of eating disorders.
  • Findings are expected to inform personalized medicine and just-in-time interventions for individuals with eating disorders.