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Impact of Intravascular Brachytherapy on Patient-Reported Outcomes in Patients with Coronary Artery Disease

Sahil Rawal1, Abhishek C Sawant1, Meenakshi Sridhar1

  • 1University Medical Center, Phoenix, AZ, USA.

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|June 18, 2020
PubMed

Insights

Intravascular brachytherapy (VBT) significantly improves patient-reported outcomes for in-stent restenosis. Quality of life, angina frequency, and activity levels showed sustained improvement post-treatment.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Radiation Oncology

Background:

  • Intravascular brachytherapy (VBT) is an established treatment for in-stent restenosis (ISR).
  • Patient-reported outcomes (PROs) following VBT for ISR remain incompletely understood.
  • This study investigates the impact of VBT on PROs in patients with ISR.

Purpose of the Study:

  • To evaluate the effect of VBT on patient-reported outcomes in managing in-stent restenosis.
  • To assess changes in quality of life, angina frequency, and physical activity following VBT.

Main Methods:

  • A cohort of 51 patients undergoing VBT for coronary ISR between January 2018 and September 2019 was analyzed.
  • Data collected included baseline characteristics, procedural outcomes, and adverse events.
  • Patients completed the Seattle Angina Questionnaire-7 (SAQ-7) at baseline, 1 month, and 6 months post-VBT.

Main Results:

  • The mean SAQ-7 summary score significantly improved from 53.2 to 83 at 30 days (p < .001), with sustained improvement at long-term follow-up.
  • Significant improvements were observed in Quality of Life (QoL) and angina frequency components of the SAQ-7.
  • Activity limitations also showed significant improvement, with results evident at 1 month and sustained up to a median follow-up of 17 months.

Conclusions:

  • VBT is associated with significant improvements in patient-reported outcomes for in-stent restenosis.
  • These improvements in quality of life and symptom burden are observed early and sustained over time.
  • VBT represents an effective treatment option for enhancing patient well-being in ISR management.
Abstract

Keywords:
Instent restenosisIntravascular brachytherapyPatient reported outcomesQuality of life

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